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Answer: The standard protocol is 1x weekly at the same time (e.g., always Monday morning)

doi:10.1186/s12902-021-00816-4

One prevailing theory is that tirzepatide is an imbalanced and biased GLP-1 RA with very low efficacy for recruitment of -arrestin, whilst is acting as an unbiased GIP agonist with full efficacy for -arrestin recruitment [51, 52]